Julie M Miwa

Work:

US Patent:

20080221013, Sep 11, 2008

Filed:

Sep 4, 2007

Appl. No.:

11/899406

Inventors:

Julie Miwa - New York NY, US
Nathaniel Heintz - Pehlem Manor NY, US
Ayse Begum Tekinay - Clifton NJ, US

International Classification:

A61K 38/00
A61P 25/00

US Classification:

514 2

Abstract:

Disclosed herein are compositions and methods for the treatment or prevention of neurological disorders using lynx compounds. The invention further discloses compositions and methods for the modulation of acetylcholine receptor activity.

US Patent:

20100004162, Jan 7, 2010

Filed:

Dec 18, 2002

Appl. No.:

10/322359

Inventors:

Nathaniel Heintz - Pelham Manor NY, US
Julie M. Miwa - New York NY, US

International Classification:

A61K 38/17
C07K 14/47
C07K 16/18
C12N 5/10
C07H 21/04
C12N 1/21
C12N 1/19
C12N 5/06
C12N 5/04
C12N 5/08
C12P 21/02
C12Q 1/68
C12N 7/00
C07H 21/02

US Classification:

514 12, 530350, 5303879, 435325, 5303913, 536 235, 536 2431, 43525233, 43525234, 43525231, 43525235, 4352542, 435358, 435419, 435348, 435366, 435 691, 435 6, 4352351, 536 231

Abstract:

The present invention provides a novel family of polypeptides which are ligand-gated channel receptor accessory molecules or ligands, denoted Lynx. This invention provides an isolated polypeptide comprising an amino acid sequence of a Lynx polypeptide in which the amino acid sequence is set forth in SEQ ID NO:2, SEQ ID NO:4 or SEQ ID NO:15, including fragments, mutants, variants, analogs, homologs, or derivatives, thereof. This invention further provides an isolated immunogenic polypeptide comprising an amino acid sequence of a Lynx polypeptide and relates to antibodies of Lynx polypeptides and the use of such antibodies. The invention provides an isolated nucleic acid encoding a polypeptide comprising an amino acid sequence of a Lynx polypeptide. This invention provides pharmaceutical compositions and diagnostic and therapeutic methods of use of the isolated polypeptides and nucleic acids of the present invention. Assays for compounds which mimic, alter or inactivate the polypeptides of the present invention for use in therapy are also provided. The present invention further relates to methods of isolating Lynx polypeptides and the nucleic acids encoding such polypeptides.