Kenneth B Sloan

US Patent:

8540976, Sep 24, 2013

Filed:

Apr 1, 2010

Appl. No.:

13/257775

Inventors:

James Klein Leonard - Madison WI, US
Kenneth Berry Sloan - Gainesville FL, US
Kenneth Boone Wagener - Gainesville FL, US

Assignee:

University of Florida Research Foundation, Inc. - Gainesville FL

International Classification:

A61K 31/00

US Classification:

424 7806, 424401, 424 7802

Abstract:

A poly(non-conjugated diene) based sunscreen has a plurality of repeating units where each repeating unit has at least one UV absorbing chromophore that is situated between and connected by chains to two mono-ene units where each UV absorbing chromophore absorb UVA and UVB light. The poly(non-conjugated diene) based sunscreen can be included with a vehicle for application to the skin to prevent sunburn. The poly(non-conjugated diene) based sunscreen can be prepared by acyclic diene metathesis polymerization.

US Patent:

42217873, Sep 9, 1980

Filed:

Jul 20, 1979

Appl. No.:

6/059380

Inventors:

Nicholas S. Bodor - Gainesville FL
Kenneth B. Sloan - Eudora KS

Assignee:

INTERx Research Corporation - Lawrence KS

International Classification:

C07J 1700
C07J 500
A61K 3158

US Classification:

424241

Abstract:

Transient, C-21 and/or C-17 esteramide prodrugs of the anti-inflammatory corticosteroids, prepared by esterification of hydroxy steroids, are disclosed.

US Patent:

43139566, Feb 2, 1982

Filed:

Dec 28, 1979

Appl. No.:

6/108055

Inventors:

Nicholas S. Bodor - Gainesville FL
Kenneth B. Sloan - Eudora KS
Stefano A. Pogany - Lawrence KS

Assignee:

INTERx Research Corp. - Lawrence KS

International Classification:

C07C14940
A61K 31265
C07C 7946
C07C10172
C07C10200
C07C10144
A61K 31165
C07C10320
C07C 9716
C09F 508
C07C15300
C07C 6976
C07C 6900
C07C 6702
C07C10120
C07C 6974
C07C 6702
A61K 3125
A61K 31235
A61K 31245
A61K 3122
A61K 3126
A61K 31255
A61K 31275
A61K 31215
C07C10130
C07C10102
C07C 6966
C07C 6934
A61K 3123
A61K 31225
A61K 3122
A61K 3116
C07C10100
C07C 7940
C07C10126

US Classification:

424301

Abstract:

Novel, transient prodrug forms of the phenolic dihydroxy sympathomimetic amines have (i) the structural formula (I): ##STR1## wherein X is O, S or NR. sup. 5 ; n is 1 or 2; R. sup. 1 is the monodehydroxylated residue of a phenolic, nuclear dihydroxy natural sympathetic or sympathomimetic amine when n is 1, and the didehydroxylated residue of a phenolic, nuclear dihydroxy natural sympathetic or sympathomimetic amine when n is 2; R. sup. 2 is selected from the group consisting of straight or branched chain alkyl having from 1 to 20 carbon atoms; aryl having from 6 to 10 carbon atoms; cycloalkyl having from 3 to 8 carbon atoms; alkenyl having from 2 to 20 carbon atoms; cycloalkenyl having from 4 to 8 carbon atoms; alkynyl having from 2 to 20 carbon atoms; aralkyl, alkaryl, aralkenyl, aralkynyl, alkenylaryl, alkynylaryl, loweracyloxyalkyl, and carboxyalkyl, wherein alkyl, aryl, alkenyl and alkynyl are as defined above; saturated or unsaturated monoheterocyclic or polyheterocyclic, or fused heterocyclic, containing from 1 to 3 of any one or more of the hetero atoms N, S or O in each heterocyclic ring thereof and each such ring being from 3- to 8-membered; and mono-or poly-substituted derivatives of the above, each of said substituents being selected from the group consisting of lower alkyl, lower alkoxy, lower acyl, lower acyloxy, halo, haloloweralkyl, cyano, carbethoxy, loweralkylthio, amino, nitro, loweralkylamino, diloweralkylamino, carboxyl, carbamyl, loweralkylcarbamyl, diloweralkylcarbamyl and ##STR2## wherein R. sup. 4 is hydrogen or alkyl having from 1 to 10 carbons; R. sup. 3 is hydrogen, R. sup.

US Patent:

49754335, Dec 4, 1990

Filed:

Jan 31, 1989

Appl. No.:

7/304272

Inventors:

Kenneth B. Sloan - Gainesville FL

Assignee:

University of Florida - Gainesville FL

International Classification:

A61K 31505
A61K 31555
C07D23947

US Classification:

514274

Abstract:

A compound of the formula: ##STR1## wherein: R and R. sub. 1 may be the same or different and are selected from the group consisting of H; cycloalkyl groups having up to 10 carbon atoms; or straight or branched chain alkyl, alkenyl or alkynyl of 1 to 10 carbon atoms; R. sub. 2 and R. sub. 3 together with the nitrogen atom to which they are bonded form a pyrrolidine, piperidine, N-methyl piperazine, piperazine or morpholine ring; or a non-toxic pharmaceutically acceptable salt, adduct, oxide or other derivative thereof; and pharmaceutical compositions adapted for topical administration to a human or non-human animal and methods of topically administering the compositions to humans and non-human animals.

US Patent:

42397570, Dec 16, 1980

Filed:

Jul 24, 1979

Appl. No.:

6/060220

Inventors:

Nicholas S. Bodor - Gainesville FL
Kenneth B. Sloan - Eudora KS

Assignee:

INTERx Research Corporation - Lawrence KS

International Classification:

C07J 7100

US Classification:

424241

Abstract:

Novel 3,2'-spiro(1',3'-thiazolidine) compounds which are transient prodrug forms of known anti-inflammatory corticosteroids are disclosed. The subject compounds can be prepared by known methods, for example, by reacting the corresponding 3-keto steroids with a thiazolidine forming reagent such as an L-cysteine alkyl ester. Preferred compounds are derived from such known anti-inflammatory corticosteroids as cortisone acetate, hydrocortisone, prednisone, prednisolone and the like.

US Patent:

42799007, Jul 21, 1981

Filed:

Jul 27, 1979

Appl. No.:

6/061177

Inventors:

Nicholas S. Bodor - Gainesville FL
Kenneth B. Sloan - Eudora KS

Assignee:

Intrex Research Corporation - Lawrence KS

International Classification:

A61K 358

US Classification:

424241

Abstract:

Novel 3,2'-spiro(1',3'-thiazolidine) compounds which are transient prodrug forms of known 6- and/or 9-haloglucocorticosteroids are described. The subject prodrugs provide improved delivery of the prior art steroids for therapeutic purposes, particularly in alleviating inflammation, and can be prepared by known methods, for example, by reacting the corresponding 3-keto steroids with a thiazolidine forming reagent such as an L-cysteine alkyl ester.

US Patent:

48450812, Jul 4, 1989

Filed:

Sep 12, 1986

Appl. No.:

6/906468

Inventors:

Kenneth B. Sloan - Gainesville FL

Assignee:

University of Florida - Gainesville FL

International Classification:

A61K 31495
C07D23910
C07D47328

US Classification:

5142322

Abstract:

N-methylamino derivatives of biologically active substances which have enhanced delivery across topical membranes and pharmaceutical compositions adapted for topical administration containing same.

US Patent:

56101600, Mar 11, 1997

Filed:

Nov 22, 1994

Appl. No.:

8/347108

Inventors:

Kenneth B. Sloan - Gainesville FL
Howard D. Beall - Gainesville FL

International Classification:

A61K 31505

US Classification:

514274

Abstract:

A pharmaceutical composition in unit dosage form adapted for topical administration to a human or non-human animal in need thereof comprising a pharmacologically effective amount of a prodrug of 5-fluorouracil having the formula: ##STR1## wherein R. sub. 3 is bonded to C=O by a carbon-to-carbon bond and is a group such that the prodrug (1) has an enhanced delivery across topical membranes and (2) hydrolyzes after delivery to 5-fluorouracil.

Location:

United States

Location:

United States

Location:

United States