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Paul Labhart

age ~66

from San Diego, CA

Also known as:
  • Ya Ping Labhart
12519 Caminito Mira Del Mar, San Diego, CA 92130858-7922208

Paul Labhart Phones & Addresses

  • 12519 Caminito Mira Del Mar, San Diego, CA 92130 • 858-7922208
  • La Jolla, CA
  • Del Mar, CA
  • Seattle, WA

Work

  • Position:
    Professional/Technical

Education

  • Degree:
    High school graduate or higher

Us Patents

  • Methods For Global Profiling Gene Regulatory Element Activity

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  • US Patent:
    20040058356, Mar 25, 2004
  • Filed:
    Apr 30, 2003
  • Appl. No.:
    10/426734
  • Inventors:
    Mary Warren - Solana Beach CA,
    Christopher Adams - San Diego CA,
    Paul Labhart - San Diego CA,
    Brian Egan - San Diego CA,
    Marc Ballivet - Geneva,
  • International Classification:
    C12Q001/68
  • US Classification:
    435/006000
  • Abstract:
    The present invention provides methods for profiling, in a global manner, the activity of gene regulatory elements in cells, including eukaryotic and prokaryotic cells. The methods involve analysis of regulatory element complexes formed under cell-free conditions or within cells (sometimes called “in vivo”). In accordance with the invention, cells can be in any state of metabolism, resting, growing, normal, mutant, diseased or differentiating. The gene regulatory element activity profiles generated for the cells in different cell populations are compared to determine differences in gene regulatory activity and overall gene expression between or among different types or states of cells.
  • Methods For Determining The Bilogical Effects Of Compounds On Gene Expression

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  • US Patent:
    20040048262, Mar 11, 2004
  • Filed:
    Jul 8, 2003
  • Appl. No.:
    10/250802
  • Inventors:
    Christopher Adams - San Diego CA,
    Paul Labhart - San Diego CA,
    Mary Harper - San Diego CA,
  • International Classification:
    C12Q001/68
  • US Classification:
    435/006000
  • Abstract:
    Methods for determining one or more biological effects of a compound on gene expression are described. These methods involve obtaining a nuclear extract from cells exposed to a compound and then combining the nuclear extract with a nucleic acid, or library of nucleic acids, containing-one or more regulatory elements under conditions that allow formation of cis/trans complexes between the regulatory elements and components (e.g., DNA binding proteins) of the nuclear extract. The complexes so formed are then compared with complexes formed using nuclear extracts obtained the same but untreaed cells and the compound. Differences between the comlexes formed as a result of exposure of teh cells to the compound can then be assessed. The methods of th einvenion are preferably carried out in a high throughput format, and are useful, for example, to assess efficacy, toxicity, and mechanism of action of a compound. Accordingly, the invention will be useful in developing new drugs, and in better understanding and improving compounds already in use or under development.

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