Prabha N. Ibrahim - Mountain View CA, US Dean R. Artis - Kensington CA, US Ryan Bremer - Oakland CA, US Chao Zhang - Moraga CA, US Jiazhong Zhang - Foster City CA, US James Tsai - Vallejo CA, US Klaus-Peter Hirth - San Francisco CA, US Gideon Bollag - Orinda CA, US Wayne Spevak - Berkeley CA, US Hanna Cho - Oakland CA, US Samuel J. Gillette - Oakland CA, US Shenghua Shi - San Diego CA, US
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
Compounds And Methods For Kinase Modulation, And Indications Therefor
Wayne Spevak - Berkeley CA, US Hanna Cho - Oakland CA, US Prabha N. Ibrahim - Mountain View CA, US Shenghua Shi - San Diego CA, US Samuel J. Gillette - Oakland CA, US Hongyao Zhu - Berkeley CA, US
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
Compounds And Methods For Kinase Modulation, And Indications Therefor
Prabha N. Ibrahim - Mountain View CA, US Dean R. Artis - Kensington CA, US Ryan Bremer - Oakland CA, US Gaston Habets - Pleasant Hill CA, US Marika Nespi - Berkeley CA, US Chao Zhang - Moraga CA, US Jiazhong Zhang - Foster City CA, US Yong-Liang Zhu - Fremont CA, US Rebecca Zuckerman - Alameda CA, US Brian West - San Francisco CA, US Yoshisa Suzuki - El Sobrante CA, US Jianming Tsai - Vallejo CA, US Klaus-Peter Hirth - San Francisco CA, US Gideon Bollag - Orinda CA, US Wayne Spevak - Berkeley CA, US Hanna Cho - Oakland CA, US Samuel J. Gillette - Oakland CA, US Guoxian Wu - Palo Alto CA, US Hongyao Zhu - Berkeley CA, US Shenghua Shi - San Diego CA, US
Assignee:
Plexxikon Inc. - Berkeley CA
International Classification:
C07D 413/14 C07D 401/14 C07D 471/04 C07F 7/02
US Classification:
544127, 544362, 546 14, 546113
Abstract:
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
Compounds And Methods For Kinase Modulation, And Indications Therefor
Prabha N. Ibrahim - Mountain View CA, US Dean R. Artis - Kensington CA, US Ryan Bremer - Oakland CA, US Chao Zhang - Moraga CA, US Jiazhong Zhang - Forster City CA, US Jianming Tsai - Vallejo CA, US Klaus-Peter Hirth - San Francisco CA, US Gideon Bollag - Orinda CA, US Wayne Spevak - Berkeley CA, US Hanna Cho - Oakland CA, US Samuel J. Gillette - Oakland CA, US Shenghua Shi - San Diego CA, US
Assignee:
Plexxikon Inc. - Berkeley CA
International Classification:
A61K 31/535
US Classification:
5142345, 51425304, 514300, 435184, 546113
Abstract:
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
Dean Artis - Kensington CA, US Ryan Bremer - Oakland CA, US Samuel Gillette - Oakland CA, US Clarence Hurt - San Ramon CA, US Prabha Ibrahim - Mountain View CA, US Rebecca Zuckerman - Alameda CA, US
International Classification:
G01N033/53 G06F019/00 G01N033/48 G01N033/50
US Classification:
435007100, 702019000
Abstract:
Molecular scaffolds for compounds active on protein kinases are described, along with methods for using such scaffolds for kinase ligand development. The use of kinase structural information, exemplified with PIM-1 crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate particular kinases.
Compounds And Methods For Kinase Modulation, And Indications Therefor
Wayne Spevak - Berkeley CA, US Hanna Cho - Oakland CA, US Prabha N. Ibrahim - Mountain View CA, US Shenghua Shi - San Diego CA, US Samuel J. Gillette - Oakland CA, US Hongyao Zhu - Berkeley CA, US
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
Compounds And Methods For Kinase Modulation, And Indications Therefor
Prabha N. Ibrahim - Mountain View CA, US Dean R. Artis - Kensington CA, US Ryan Bremer - Oakland CA, US Gaston Habets - Pleasant Hill CA, US Marika Nespi - Berkeley CA, US Chao Zhang - Moraga CA, US Jiazhong Zhang - Foster City CA, US Yong-Liang Zhu - Fremont CA, US Rebecca Zuckerman - Alameda CA, US Brian West - San Francisco CA, US Yoshisa Suzuki - San Pablo CA, US James Tsai - Vallejo CA, US Klaus-Peter Hirth - San Francisco CA, US Gideon Bollag - Orinda CA, US Wayne Spevak - Berkeley CA, US Hanna Cho - Oakland CA, US Samuel J. Gillette - Oakland CA, US Guoxian Wu - Palo Alto CA, US Hongyao Zhu - Berkeley CA, US Shenghua Shi - San Diego CA, US
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
Compounds And Methods For Kinase Modulation, And Indications Therefor
DEAN R. ARTIS - KENSINGTON CA, US RYAN BREMER - OAKLAND CA, US GASTON HABETS - PLEASANT HILL CA, US MARIKA NESPI - BERKELEY CA, US CHAO ZHANG - MORAGA CA, US JIAZHONG ZHANG - FOSTER CITY CA, US YONG-LIANG ZHU - FREMONT CA, US REBECCA ZUCKERMAN - ALAMEDA CA, US BRIAN WEST - SAN FRANCISCO CA, US YOSHISA SUZUKI - EL SOBRANTE CA, US JIANMING TSAI - VALLEJO CA, US KLAUS-PETER HIRTH - SAN FRANCISCO CA, US GIDEON BOLLAG - ORINDA CA, US WAYNE SPEVAK - BERKELEY CA, US HANNA CHO - OAKLAND CA, US SAMUEL J. GILLETTE - OAKLAND CA, US GUOXIAN WU - PALO ALTO CA, US HONGYAO ZHU - BERKELEY CA, US SHENGHUA SHI - SAN DIEGO CA, US
International Classification:
C07D 471/04
US Classification:
5142345, 514300, 51425304
Abstract:
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.