Wenjiang Fu

US Patent:

20090137417, May 28, 2009

Filed:

Oct 16, 2008

Appl. No.:

12/253106

Inventors:

Wenjiang Fu - Okemos MI, US
Minping Qian - Bejing, CN
Lin Wan - Bejing, CN
Ke Lian Sun - Lansing MI, US

International Classification:

C40B 30/04

US Classification:

506 9

Abstract:

This invention contemplates an accurate and efficient estimation of gene copy number using oligonucleotide microarrays. The method integrates gene copy number data obtained from perfect match and mismatch probe sequence structure intensities and probe binding affinities. In one embodiment, an accurate determination of single nucleotide polymorphisms (SNPs) sequences is obtained. In another embodiment, an accurate detection and determination of DNA copy number alteration is obtained. In another embodiment, an accurate estimation for RNA gene expression is obtained.

US Patent:

20100222225, Sep 2, 2010

Filed:

Apr 7, 2010

Appl. No.:

12/755637

Inventors:

Wenjiang Fu - Okemos MI, US
Yalu Wen - East Lansing MI, US
Ming Li - Lansing MI, US

International Classification:

C40B 30/02

US Classification:

506 8

Abstract:

This invention contemplates an accurate and efficient estimation of gene copy number using oligonucleotide microarrays. The method integrates gene copy number data obtained from perfect match and mismatch probe sequence structure intensities and probe binding affinities. In one embodiment, an accurate determination of single nucleotide polymorphisms (SNPs) sequences is obtained. In another embodiment, an accurate detection and determination of DNA copy number alteration is obtained. In another embodiment, an accurate estimation for RNA gene expression is obtained.